Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:7450461.
doi: 10.1155/2016/7450461. Epub 2016 Apr 27.

MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

Katerina Popovska-Jankovic  1 , Predrag Noveski  1 , Ljubinka Jankovic-Velickovic  2 , Slavica Stojnev  2 , Rade Cukuranovic  3 , Vladisav Stefanovic  4 , Draga Toncheva  5 , Rada Staneva  5 , Momir Polenakovic  1 , Dijana Plaseska-Karanfilska  1
Affiliations

MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

Katerina Popovska-Jankovic et al. Biomed Res Int. 2016.

Abstract

Balkan endemic nephropathy (BEN) is a disease that affects people that live in the alluvial plains along the tributaries of the Danube River in the Balkan region. BEN is a chronic tubulointerstitial disease with a slow progression to terminal renal failure and has strong association with upper tract urothelial carcinoma (UTUC). There are several hypotheses about the etiology of BEN, but only the toxic effect of aristolochic acid has been confirmed as a risk factor in the occurrence of the disease. Aberrantly expressed miRNAs have been shown to be associated with many types of cancers. A number of studies have investigated the expression of microRNAs in urothelial carcinoma, mainly on urothelial bladder cancer, and only a few have included patients with UTUC. Here we present the first study of microRNA profiling in UTUC tissues from patients with BEN (BEN-UTUC) and patients with UTUC from nonendemic Balkan regions (non-BEN-UTUC) in comparison to normal kidney tissues. We found 10 miRNAs that were differentially expressed in patients with BEN-UTUC and 15 miRNAs in patients with non-BEN-UTUC. miRNA signature determined in BEN-UTUC patients differs from the non-BEN-UTUC patients; only miR-205-5p was mutual in both groups.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Venn diagrams of differentially expressed microRNAs in BEN-UTUC samples (a) and non-BEN-UTUC samples (b), both in comparison to normal kidney samples and determined by GeneSpring (GS) and R Bioconductor (RB) statistical programs.
Figure 2
Figure 2
Comparison of qPCR and microarray data in BEN-UTUC samples.
Figure 3
Figure 3
Comparison of qPCR and microarray data in non-BEN-UTUC samples.
Figure 4
Figure 4
Heat maps of differentially expressed miRNAs and target gene related pathways derived from DIANA-miRPath v.3.0 analysis determined by “pathway union” option in (a) BEN-UTUC and (b) non-BEN-UTUC patients.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Polenakovic M., Stefanovic V. Balkan nephropathy. In: Cameron J. S., Davison A. M., Grunfeld J. P., Kerr D., Ritz E., editors. Oxford Textbook of Clinical Nephrology. 1st. Oxford, UK: Oxford University Press; 1992. pp. 857–866.
    1. Djukanović L., Radovanović Z. Balkan endemic nephropathy. In: De Broe M. E., Porter G. A., Bennett W. M., Verpooten G. A., editors. Clinical Nephrotoxins. Dordrecht, The Netherlands: Kluwer Academic Publishers; 2003. pp. 587–601.
    1. Stefanovic V., Radovanovic Z. Balkan endemic nephropathy and associated urothelial cancer. Nature Clinical Practice Urology. 2008;5(2):105–112. doi: 10.1038/ncpuro1019. - DOI - PubMed
    1. Stefanovic V. Current status and research beyond year 2010 in Balkan endemic nephropathy. BANTAO Journal. 2009;7(2):4–9.
    1. Stefanovic V., Polenakovic M., Toncheva D. Urothelial carcinoma associated with Balkan endemic nephropathy. A worldwide disease. Pathologie Biologie. 2011;59(5):286–291. doi: 10.1016/j.patbio.2009.05.002. - DOI - PubMed

LinkOut - more resources