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. 2016 May 24;11(5):e0156113.
doi: 10.1371/journal.pone.0156113. eCollection 2016.

Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology

Umberto Vespasiani-Gentilucci  1 , Paolo Gallo  1 , Fiorella Piemonte  2 , Elisabetta Riva  3 , Aldostefano Porcari  1 , Ferruccio Vorini  1 , Giulia Tozzi  2 , Livia Piccioni  3 , Giovanni Galati  1 , Antonio De Vincentis  1 , Simone Carotti  4 , Sergio Morini  4 , Jessica D'Amico  2 , Silvia Angeletti  5 , Claudio Pedone  6 , Antonio Picardi  1
Affiliations

Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology

Umberto Vespasiani-Gentilucci et al. PLoS One. .

Abstract

Liver cirrhosis is characterized by a severe acquired reduction of LAL-activity, the precise causes and consequences of which need to be further addressed. DBS-determined lysosomal enzyme activities seem to be affected by white blood cell and platelet counts, and the specificity of these tests can be reduced when applied to determined populations, such as cirrhotics.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
DBS-determined LAL activity in cryptogenic cirrhotics, cirrhotics of known etiology and healthy subjects (Panel A). Percentages of cirrhotic patients and healthy subjects with normal (≥0.8 nmol/spot/h), mildly reduced (range 0.4–0.8 nmol/spot/h), or severely reduced LAL activity (<0.4 nmol/spot/h) (Panel B).
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