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. 1989;227(2):180-3.
doi: 10.1007/BF02169793.

Sorbitol metabolism in retina studied in vitro

P Naeser  1 , S E Brolin, U J Eriksson
Affiliations

Sorbitol metabolism in retina studied in vitro

P Naeser et al. Graefes Arch Clin Exp Ophthalmol. 1989.

Abstract

A new method is described which allows study of the retinal sorbitol metabolism in vitro. Bovine retinal tissue was incubated in tissue culture medium for 24 h and after this time showed only small morphological changes. The sorbitol content doubled at a glucose level of 5.5 mM compared with freshly prepared noncultured retina. Increasing glucose concentrations led to a gradual increase of the sorbitol content. Supplementation of the culture medium with fructose likewise enhanced the retinal sorbitol accumulation. An aldose reductase inhibitor (ICI 128436; Statil) significantly decreased the sorbitol content.

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