Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989;227(2):180-3.
doi: 10.1007/BF02169793.

Sorbitol metabolism in retina studied in vitro

P Naeser  1 , S E Brolin, U J Eriksson
Affiliations

Sorbitol metabolism in retina studied in vitro

P Naeser et al. Graefes Arch Clin Exp Ophthalmol. 1989.

Abstract

A new method is described which allows study of the retinal sorbitol metabolism in vitro. Bovine retinal tissue was incubated in tissue culture medium for 24 h and after this time showed only small morphological changes. The sorbitol content doubled at a glucose level of 5.5 mM compared with freshly prepared noncultured retina. Increasing glucose concentrations led to a gradual increase of the sorbitol content. Supplementation of the culture medium with fructose likewise enhanced the retinal sorbitol accumulation. An aldose reductase inhibitor (ICI 128436; Statil) significantly decreased the sorbitol content.

PubMed Disclaimer

References

    1. Invest Ophthalmol Vis Sci. 1983 Nov;24(11):1519-24 - PubMed
    1. Acta Ophthalmol (Copenh). 1987 Dec;65(6):693-8 - PubMed
    1. Proc Soc Exp Biol Med. 1987 Dec;186(3):348-54 - PubMed
    1. Invest Ophthalmol. 1974 Oct;13(10):713-24 - PubMed
    1. N Engl J Med. 1973 Apr 19;288(16):831-6 - PubMed

Publication types