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. 1989 Apr;22(4):369-73.
doi: 10.1002/mrd.1120220403.

Failure of spermatozoa from T/t mice to fertilize in vitro is overcome by zona drilling

T Ahmad  1 , J C Conover, M M Quigley, R L Collins, A J Thomas Jr, R B Gwatkin
Affiliations

Failure of spermatozoa from T/t mice to fertilize in vitro is overcome by zona drilling

T Ahmad et al. Gamete Res. 1989 Apr.

Abstract

Failure of epididymal spermatozoa from T/t mutant mice, but not from t/t individuals, to fertilize oocytes in vitro was partially overcome by opening a small aperture in the zona pellucida with acidified Tyrode's solution to permit direct access of the spermatozoon to the vitellus. This study provides a model system to evaluate requirements for successful zona drilling in the treatment of human infertility and further insights into the effects of the t complex on sperm fertility.

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