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. 2016 Apr 29:7:1570-5.
doi: 10.1016/j.dib.2016.04.055. eCollection 2016 Jun.

Dataset of mitochondrial genome variants associated with asymptomatic atherosclerosis

Margarita A Sazonova  1 , Andrey V Zhelankin  2 , Valeria A Barinova  2 , Vasily V Sinyov  2 , Zukhra B Khasanova  2 , Anton Y Postnov  2 , Igor A Sobenin  1 , Yuri V Bobryshev  3 , Alexander N Orekhov  4
Affiliations

Dataset of mitochondrial genome variants associated with asymptomatic atherosclerosis

Margarita A Sazonova et al. Data Brief. .

Abstract

This dataset report is dedicated to mitochondrial genome variants associated with asymptomatic atherosclerosis. These data were obtained using the method of next generation pyrosequencing (NGPS). The whole mitochondrial genome of the sample of patients from the Moscow region was analyzed. In this article the dataset including anthropometric, biochemical and clinical parameters along with detected mtDNA variants in patients with carotid atherosclerosis and healthy individuals was presented. Among 58 of the most common homoplasmic mtDNA variants found in the observed sample, 7 variants occurred more often in patients with atherosclerosis and 16 variants occurred more often in healthy individuals.

Keywords: Asymptomatic atherosclerosis; Homoplasmic; Mitochondrial genome; mtDNA variant.

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Figures

Fig. 1.
Fig. 1
The most common mtDNA variants that were more frequent (with ratio >=1.5) in controls compared with atherosclerotic patients. For positions in coding region, names of genes are given in brackets.
Fig. 2.
Fig. 2
The most common mtDNA variants that were more frequent (with ratio >=1.5) in atherosclerotic patients compared with controls. For positions in coding region, names of genes are given in brackets.
See this image and copyright information in PMC

References

    1. Miasoedova V.A., Kirichenko T.V., Orekhova V.A., Sobenin I.A., Mukhamedova N.M., Martirosian D.M., Karagodin V.P., Orekhov A.N. Study of intima-medial thickness (IMT) of the carotid arteries as an indicator of natural atherosclerosis progress in Moscow population. Patol. Fiziol. Eksp. Ter. 2012;3:104–108. - PubMed
    1. Aladinsky V.A., Nikiforov N.G., Orekhova V.A., Melnichenko A.A., Karagodin V.P., Sobenin I.A., Orekhov A.N. Direct antiatherosclerotic therapy: possible approaches, results of clinical trials. Patol Fiziol Eksp Ter. 2013;4:76–83. - PubMed
    1. Chernova E.V., Sobenin I.A., Melnichenko A.A., Karagodin A.P., Orekhov A.N. Serum atherogenicity as a pathogenetic target for direct anti-atherosclerotic therapy. Pathogenesis. 2013;11:28–41.
    1. Feoktistov A.S., Gavrilin M.A., Karagodin V.P., Bobryshev Y.V., Orekhov A.N. Promising therapeutic approaches to inhibition of atherogenic modification (desialylation) of low density lipoproteins. Pathogenesis. 2013;11:46–50.
    1. Temchenko A.V., Nikiforov N.G., Orekhova V.A., Melnichenko A.A., Karagodin V.H., Sobenin I.A., Orekhov A.N. Achievements in therapy of atherosclerosis. Pathogenesis. 2013;11:11–18.

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