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Comment
. 2016 May 24;110(10):2133-5.
doi: 10.1016/j.bpj.2016.04.008.

Extruding Loops to Make Loopy Globules?

Alexander Y Grosberg  1
Affiliations
Comment

Extruding Loops to Make Loopy Globules?

Alexander Y Grosberg. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Cartoon representation of the loop extrusion model. Extruders (a) and (b) have already produced large loops; (c) and (d) are only starting. Extruders (e–g) are presently disconnected from the fiber; they diffuse around, and will initiate new loops once they absorb somewhere on the fiber. Extruder (a) is already approaching the (mirror symmetric) stop signs, while (b) and (d) have a long way to go. (Black arrows) Directions in which fiber is pushed by every extruder. Two large loops are shown to collide in three dimensions. To see this figure in color, go online.
See this image and copyright information in PMC

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References

    1. Dekker J., Rippe K., Kleckner N. Capturing chromosome conformation. Science. 2002;295:1306–1311. - PubMed
    1. Lieberman-Aiden E., van Berkum N.L., Dekker J. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science. 2009;326:289–293. - PMC - PubMed
    1. Kirmes I., Szczurek A., Reid G. A transient ischemic environment induces reversible compaction of chromatin. Genome Biol. 2015;16:246. - PMC - PubMed
    1. Goloborodko A., Marko J.F., Mirny L.A. Chromosome compaction by active loop extrusion. Biophys. J. 2016;110:2162–2168. - PMC - PubMed
    1. Fudenberg, G., M. Imakaev, …, L. Mirny. 2015. Formation of chromosomal domains by loop extrusion. http://biorxiv.org/content/early/2015/08/14/024620. - PMC - PubMed

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