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. 2016 Aug:62:32-47.
doi: 10.1016/j.jbi.2016.05.006. Epub 2016 May 17.

The INTEGRATE project: Delivering solutions for efficient multi-centric clinical research and trials

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Free article

The INTEGRATE project: Delivering solutions for efficient multi-centric clinical research and trials

Haridimos Kondylakis et al. J Biomed Inform. 2016 Aug.
Free article

Abstract

The objective of the INTEGRATE project (http://www.fp7-integrate.eu/) that has recently concluded successfully was the development of innovative biomedical applications focused on streamlining the execution of clinical research, on enabling multidisciplinary collaboration, on management and large-scale sharing of multi-level heterogeneous datasets, and on the development of new methodologies and of predictive multi-scale models in cancer. In this paper, we present the way the INTEGRATE consortium has approached important challenges such as the integration of multi-scale biomedical data in the context of post-genomic clinical trials, the development of predictive models and the implementation of tools to facilitate the efficient execution of postgenomic multi-centric clinical trials in breast cancer. Furthermore, we provide a number of key "lessons learned" during the process and give directions for further future research and development.

Keywords: Cohort selection; Collaborative environment; Innovative biomedical applications; Post-genomic clinical trials; Predictive models; Quantitative analysis; Semantic integration.

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