Prebiotic nut compounds and human microbiota

doi:10.1080/10408398.2015.1096763

Review

. 2017 Sep 22;57(14):3154-3163.

doi: 10.1080/10408398.2015.1096763.

Prebiotic nut compounds and human microbiota

Rosa M Lamuel-Raventos^{1

2}, Marie-Pierre St Onge³

Affiliations

¹ a Department of Nutrition and Food Science-XARTA-INSA , School of Pharmacy, University of Barcelona , Barcelona , Spain.
² b Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN) , Instituto de Salud Carlos III , Madrid , Spain.
³ c Department of Medicine and Institute of Human Nutrition , Columbia University , New York , New York , USA.

PMID: 27224877
PMCID: PMC5646185
DOI: 10.1080/10408398.2015.1096763

Review

Prebiotic nut compounds and human microbiota

Rosa M Lamuel-Raventos et al. Crit Rev Food Sci Nutr. 2017.

. 2017 Sep 22;57(14):3154-3163.

doi: 10.1080/10408398.2015.1096763.

Authors

Rosa M Lamuel-Raventos^{1

2}, Marie-Pierre St Onge³

Affiliations

¹ a Department of Nutrition and Food Science-XARTA-INSA , School of Pharmacy, University of Barcelona , Barcelona , Spain.
² b Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN) , Instituto de Salud Carlos III , Madrid , Spain.
³ c Department of Medicine and Institute of Human Nutrition , Columbia University , New York , New York , USA.

PMID: 27224877
PMCID: PMC5646185
DOI: 10.1080/10408398.2015.1096763

Abstract

Nut consumption is clearly related to human health outcomes. Its beneficial effects have been mainly attributed to nut fatty acid profiles and content of vegetable protein, fiber, vitamins, minerals, phytosterols and phenolics. However, in this review we focus on the prebiotics properties in humans of the non-bioaccessible material of nuts (polymerized polyphenols and polysaccharides), which provides substrates for the human gut microbiota and on the formation of new bioactive metabolites and the absorption of that may partly explain the health benefits of nut consumption.

Keywords: Nuts; butyrate; fiber; polyphenols; polysaccharides; urolithins; valerolactones.

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Figures

**Figure 1.**
Prebiotic almond polysaccharides metabolism in human body.

**Figure 2.**
PAC metabolism in human body.

See this image and copyright information in PMC

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References

1. Abe L. T., Lajolo F. M. and Genovese M. I. (2010). Comparison of phenol content and antioxidant capacity of nuts. Ciência e Tecnol. Aliment. :254–259.
1. American Institute for Cancer Research (2015). No Title [Internet] Available from: <fight-cancer/tab-content/walnuts-research.html>.
1. Appeldoorn M. M., Vincken J.-P., Aura A.-M., Hollman P. C. H. and Gruppen H. (2009). Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. J. Agric. Food Chem. :1084–1092. - PubMed
1. Babio N., Toledo E., Estruch R., Ros E., Martínez-González M. A., Castañer O., Bulló M., Corella D., Arós F., Gómez-Gracia E., Ruiz-Gutiérrez V., Fiol M., Lapetra J., Lamuela-Raventos R. M., Serra-Majem L., Pintó X., Basora J., Sorlí J. V. and Salas-Salvadó J. (2014). Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ. :E649–E657. - PMC - PubMed
1. Bao Y., Han J., Hu F. B., Giovannucci E. L., Stampfer M. J., Willett W. C. and Fuchs C. S. (2013). Association of nut consumption with total and cause-specific mortality. N. Engl. J. Med. :2001–2011. - PMC - PubMed

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[1] Abe L. T., Lajolo F. M. and Genovese M. I. (2010). Comparison of phenol content and antioxidant capacity of nuts. Ciência e Tecnol. Aliment. :254–259.

[2] Abe L. T., Lajolo F. M. and Genovese M. I. (2010). Comparison of phenol content and antioxidant capacity of nuts. Ciência e Tecnol. Aliment. :254–259.

[3] American Institute for Cancer Research (2015). No Title [Internet] Available from: <fight-cancer/tab-content/walnuts-research.html>.

[4] American Institute for Cancer Research (2015). No Title [Internet] Available from: <fight-cancer/tab-content/walnuts-research.html>.

[5] Appeldoorn M. M., Vincken J.-P., Aura A.-M., Hollman P. C. H. and Gruppen H. (2009). Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. J. Agric. Food Chem. :1084–1092. - PubMed

[6] Appeldoorn M. M., Vincken J.-P., Aura A.-M., Hollman P. C. H. and Gruppen H. (2009). Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. J. Agric. Food Chem. :1084–1092. - PubMed

[7] Babio N., Toledo E., Estruch R., Ros E., Martínez-González M. A., Castañer O., Bulló M., Corella D., Arós F., Gómez-Gracia E., Ruiz-Gutiérrez V., Fiol M., Lapetra J., Lamuela-Raventos R. M., Serra-Majem L., Pintó X., Basora J., Sorlí J. V. and Salas-Salvadó J. (2014). Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ. :E649–E657. - PMC - PubMed

[8] Babio N., Toledo E., Estruch R., Ros E., Martínez-González M. A., Castañer O., Bulló M., Corella D., Arós F., Gómez-Gracia E., Ruiz-Gutiérrez V., Fiol M., Lapetra J., Lamuela-Raventos R. M., Serra-Majem L., Pintó X., Basora J., Sorlí J. V. and Salas-Salvadó J. (2014). Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ. :E649–E657. - PMC - PubMed

[9] Bao Y., Han J., Hu F. B., Giovannucci E. L., Stampfer M. J., Willett W. C. and Fuchs C. S. (2013). Association of nut consumption with total and cause-specific mortality. N. Engl. J. Med. :2001–2011. - PMC - PubMed

[10] Bao Y., Han J., Hu F. B., Giovannucci E. L., Stampfer M. J., Willett W. C. and Fuchs C. S. (2013). Association of nut consumption with total and cause-specific mortality. N. Engl. J. Med. :2001–2011. - PMC - PubMed

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Prebiotic nut compounds and human microbiota

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Prebiotic nut compounds and human microbiota

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