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Randomized Controlled Trial
. 2016 May;64(5):933-43.
doi: 10.1111/jgs.14114.

Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial

Anthony P Marsh  1 , William B Applegate  2 , Jack M Guralnik  3 , W Jack Rejeski  1 , Timothy S Church  3 , Roger A Fielding  4 , Thomas M Gill  5 , Abby C King  6   7 , Stephen B Kritchevsky  2 , Todd M Manini  8   9 , Mary M McDermott  8   9 , Anne B Newman  10 , Cynthia L Stowe  11 , Michael P Walkup  11 , Marco Pahor  8   9 , Michael E Miller  11 ; LIFE Study Investigators
Collaborators, Affiliations
Randomized Controlled Trial

Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial

Anthony P Marsh et al. J Am Geriatr Soc. 2016 May.

Abstract

Objectives: To determine whether moderate-intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants.

Design: Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years.

Setting: Eight field centers.

Participants: Sedentary men and women aged 70-89 with lower extremity physical limitations but able to walk 400-m in 15 minutes or less (N = 1,635).

Interventions: Structured, moderate-intensity PA (n = 818) at a center (2×/wk) and at home (3-4×/wk) that included aerobic, strength, balance, and flexibility training or HE (n = 817) of educational workshops and upper extremity stretching exercises.

Measurements: All-cause inpatient hospitalizations ascertained at 6-month intervals.

Results: There were 1,458 hospitalizations (49.1% of PA, 44.4% of HE; risk difference = 4.68%, 95% confidence interval (CI) = -0.18-9.54; hazard ratio (HR) = 1.16, 95% CI = 1.00-1.34). The intervention effect on incident hospitalization did not differ according to race, sex, Short Physical Performance Battery score, age, or history of cardiovascular disease or diabetes mellitus. PA was associated with higher rates of hospitalization in the middle baseline gait speed category, than HE (<0.8 m/s: HR = 0.93, 95% CI = 0.76-1.14; 0.8-1.0 m/s: HR = 1.54, 95% CI = 1.23-1.94; >1.0 m/s: HR = 1.05, 95% CI = 0.67-1.65; interaction P = .005).

Conclusion: A PA program in older adults at risk for mobility disability did not lead to a different risk of specific types of hospitalizations than a HE program overall. Baseline gait speed may be a marker for risk of hospitalization during a PA intervention, because individuals with moderate baseline gait speed in the PA group had slightly higher rates of hospitalization than those in the HE group.

Trial registration: ClinicalTrials.gov identifier: NCT01072500.

Keywords: hospitalizations; mobility disability; older adults; physical activity; safety.

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Figures

Figure 1
Figure 1
Cumulative hazards for initial in-patient hospitalization by treatment group.
Figure 2
Figure 2
Hazard Ratios (95% CI) for Hospitalizations among Baseline Subgroups
Figure 3
Figure 3
B-Spline Curve Illustrating the Relationship Between Baseline Gait Speed and Hospitalizations
Figure 4
Figure 4
Hospitalization rates by categories of 400-m walk gait speed at baseline, overall and by MedDRA SOC categories.
See this image and copyright information in PMC

References

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    1. LaCroix AZ, Leveille SG, Hecht JA, et al. Does walking decrease the risk of cardiovascular disease hospitalizations and death in older adults? J Am Geriatr Soc. 1996;44:113–120. - PubMed

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