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Editorial
. 2016 Jun;36(6):1056-7.
doi: 10.1161/ATVBAHA.116.307625.

How Does Protein Disulfide Isomerase Get Into a Thrombus?

Meenakshi Banerjee  1 , Sidney W Whiteheart  2
Affiliations
Editorial

How Does Protein Disulfide Isomerase Get Into a Thrombus?

Meenakshi Banerjee et al. Arterioscler Thromb Vasc Biol. 2016 Jun.
No abstract available

Keywords: endothelial cells; extracellular space; megakaryocytes; platelet activation; thrombosis.

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Figures

Figure 1
Figure 1. The Complexity of Platelet Organelles
In resting platelets, the various cargo (depicted in the legend) are present in secretory granules, ER-derived compartments, and other organelles. Upon activation, granule/organelle–plasma membrane fusion drives surface exposure and release of luminal cargo into the extracellular space.
See this image and copyright information in PMC

Comment on

References

    1. Bekendam RH, Flaumenhaft R. Inhibition of Protein Disulfide Isomerase in Thrombosis. Basic Clin Pharmacol Toxicol. 2016 - PubMed
    1. Flaumenhaft R, Furie B, Zwicker JI. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol. 2015;35(1):16–23. - PMC - PubMed
    1. Schulman S, Bendapudi P, Sharda A, Chen V, Bellido-Martin L, Jasuja R, Furie BC, Flaumenhaft R, Furie B. Extracellular Thiol Isomerases and Their Role in Thrombus Formation. Antioxid Redox Signal. 2016;24(1):1–15. - PMC - PubMed
    1. Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of beta3 integrins. Blood. 2012;120(3):647–655. - PMC - PubMed
    1. Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Louriero S, Ali MS, Vaiyapuri S, Schenk MP, Holbrook LM, Falet H, Jones IM, Poole AW, Kahr WHA, Gibbins JM. Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016 - PMC - PubMed

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