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. 2016 May 4:9:2615-24.
doi: 10.2147/OTT.S103893. eCollection 2016.

Tissue microRNA-21 expression predicted recurrence and poor survival in patients with colorectal cancer - a meta-analysis

Zexin Chen  1 , Hui Liu  2 , Wen Jin  2 , Zheyuan Ding  2 , Shuangshuang Zheng  2 , Yunxian Yu  2
Affiliations

Tissue microRNA-21 expression predicted recurrence and poor survival in patients with colorectal cancer - a meta-analysis

Zexin Chen et al. Onco Targets Ther. .

Abstract

Objective: MicroRNA-21 (miR-21) has been shown to play an important role in cancer prognosis. We performed a meta-analysis to evaluate the prognostic effect of miR-21 from tissues and serum on survival of the patients with colorectal cancer (CRC).

Methods: Relevant studies were identified by searching PubMed, Embase, and Cochrane Library. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) of total and subgroup analyses, for overall survival (OS) and disease-free survival (DFS), were calculated to investigate the association between miR-21 expression and CRC prognosis.

Results: Our analysis included eleven studies (3,669 subjects). In addition, four studies explored the association between miR-21 and DFS, and ten studies focused on the prognostic value of miR-21 for OS. Our results indicated that increased miR-21 expression of tissues predicted both poor DFS and OS in patients with CRC (DFS: HR =1.59, 95% CI =1.20-2.10; OS: HR =1.53, 95% CI =1.23-1.90). Consistent results were observed among colon cancer and quantitative real-time polymerase chain reaction subgroups.

Conclusion: Meta-analysis indicated that miR-21 predicted recurrence and poor survival in patients with CRC. miR-21 may be more suitable to predict cancer prognosis in colon cancer patients.

Keywords: colorectal cancer; miR-21; prognostic value.

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Figures

Figure 1
Figure 1
Methodological flow chart of the review. Abbreviations: miR-21, microRNA-21; CRC, colorectal cancer; HR, hazard ratio; OS, overall survival; DFS, disease-free survival.
Figure 2
Figure 2
Forest plots of studies evaluating HRs of miR-21 with DFS in all studies (tissue). Note: Weights are from random effects analysis. Abbreviations: HRs, hazard ratios; miR-21, microRNA-21; DFS, disease-free survival; ES, effect size; CI, confidence interval.
Figure 3
Figure 3
Forest plots of studies evaluating HRs of miR-21 with OS in all studies (tissue). Note: Weights are from random effects analysis. Abbreviations: HRs, hazard ratios; miR-21, microRNA-21; OS, overall survival; ES, effect size; CI, confidence interval.
Figure 4
Figure 4
Forest plots of studies evaluating HRs of miR-21 with OS in all studies (serum). Note: Weights are from random effects analysis. Abbreviations: HRs, hazard ratios; miR-21, microRNA-21; OS, overall survival; ES, effect size; CI, confidence interval.
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