Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May;59(3):192-6.
doi: 10.3340/jkns.2016.59.3.192. Epub 2016 May 10.

Development and Growth of the Normal Cranial Vault : An Embryologic Review

Sung-Won Jin  1 , Ki-Bum Sim  2 , Sang-Dae Kim  1
Affiliations
Review

Development and Growth of the Normal Cranial Vault : An Embryologic Review

Sung-Won Jin et al. J Korean Neurosurg Soc. 2016 May.

Abstract

Understanding the development of a skull deformity requires an understanding of the normal morphogenesis of the cranium. Craniosynostosis is the premature, pathologic ossification of one or more cranial sutures leading to skull deformities. A review of the English medical literature using textbooks and standard search engines was performed to gather information about the prenatal development and growth of the cranial vault of the neurocranium. A process of morphogenic sequencing begins during prenatal development and growth, continues postnatally, and contributes to the basis for the differential manner of growth of cranial vault bones. This improved knowledge might facilitate comprehension of the pathophysiology of craniosynostosis.

Keywords: Cranial sutures; Craniosynostosis; Embryonic development; Growth; Skull.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Skeletal structure of skull : mesenchyme for these structures is derived from neural crest (white) and paraxial mesoderm (gray). Sq : squamous, Pet : petrous.
See this image and copyright information in PMC

References

    1. Adeeb N, Mortazavi MM, Tubbs RS, Cohen-Gadol AA. The cranial dura mater : a review of its history, embryology, and anatomy. Childs Nerv Syst. 2012;28:827–837. - PubMed
    1. Caetano-Lopes J, Canhão H, Fonseca JE. Osteoblasts and bone formation. Acta Reumatol Port. 2007;32:103–110. - PubMed
    1. Cohen MM, MacLean RE. Craniosynostosis : Diagnosis, Evaluation, and Management. ed 2. New York: Oxford University Press; 2000. pp. 105–107.
    1. Dixon AD, Hoyte DA, Ronning O. Fundamentals of Craniofacial Growth. New York: CRC Press; 1997. pp. 101–102.
    1. Glorieux FH, Pettifor JM, Juppner H. Pediatric bone : Biology & Diseases. San Diego: Academic Press; 2003. pp. 77–103.

LinkOut - more resources