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. 2016 Feb 25;3(1):25-7.
doi: 10.1080/23328940.2015.1130520. eCollection 2016 Jan-Mar.

Prostaglandin E2 that triggers fever is synthesized through an endocannabinoid- dependent pathway

Bruno Conti  1
Affiliations

Prostaglandin E2 that triggers fever is synthesized through an endocannabinoid- dependent pathway

Bruno Conti. Temperature (Austin). .
No abstract available

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Figures

Figure 1.
Figure 1.
The endocannabinoid 2-AG is hydrolyzed by MAGL providing a PLA-independent source of AA. AA is the substrate for the synthesis of prostaglandin PGE2 (and other prostanoids). Genetic or pharmacological inhibition of MAGL strongly reduced fever response to LPS or IL-1β.
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Comment on

  • Comment on: Sanchez-Alavez M, et al. Monoacylglycerol lipase regulates fever response. PloS One 2015; 10:e0134437; http://dx.doi.org/10.1371/journal.pone.0134437; Kita Y, et al. Fever is mediated by conversion of endocannabinoid 2-arachidonoylglycerol to prostaglandin E2. PloS One 2015; 10:e0133663; http://dx.doi.org/10.1371/journal.pone.0133663

References

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