Genetics of systemic lupus erythematosus and Sjögren's syndrome: an update

Abstract

Purpose of review: To describe the recent studies on the genetics of systemic lupus erythematosus (SLE) and Sjögren's syndrome.

Recent findings: We overview the most recent findings on the genetic susceptibility of the diseases and provide information on their genetic similarities and differences.

Summary: SLE and Sjögren's syndrome are two closely related systemic autoimmune diseases that share multiple clinical and molecular aspects, including a significant number of susceptibility genes. Several genome-wide association studies were recently published in different populations that provide a better picture of their molecular mechanisms. It is becoming clear that their genetic architecture is quite well established, but more information is required on expression quantitative trait loci, epigenetic genome-wide analyses, gene × gene interactions and the role of rare variants.