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Review
. 2016 May;95(21):e2302.
doi: 10.1097/MD.0000000000002302.

Toll-Like Receptor 3 is Associated With the Risk of HCV Infection and HBV-Related Diseases

Pei-Liang Geng  1 , Li-Xue Song, Huaijie An, Jing-Yu Huang, Sheng Li, Xian-Tao Zeng
Affiliations
Review

Toll-Like Receptor 3 is Associated With the Risk of HCV Infection and HBV-Related Diseases

Pei-Liang Geng et al. Medicine (Baltimore). 2016 May.

Abstract

There are inconsistent data on the association of risk of hepatitis virus infection and hepatitis virus-related diseases with the toll-like receptor 3 (TLR3) gene.Several common polymorphism sites were targeted to assess the risk of HBV infection, HCV infection, and HBV-related diseases.Meta-analysis combining data for 3547 cases and 2797 controls from 8 studies was performed in this study. Pooled ORs were calculated to measure the risk of hepatitis virus infection and hepatitis virus-related diseases. Fixed-effects pooled ORs were calculated using the Mantel-Haenszel method.The TLR3 gene was associated with a significantly increased risk of HBV-related diseases among 1355 patients and 1130 controls ([pooled OR, [95%CI]: 1.30, [1.15-1.48] for dominant; 1.77, [1.35-2.31] for recessive; 1.28 [1.16-1.41] for allele frequency). Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11-2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16-0.25]). We also noted an association between rs3775291 and significantly increased risk of HBV-related diseases (2.23 [1.55-3.21]). No significant inter-study heterogeneity or publication bias was detected in the analyses.These data suggest a likely effect on the risk to infect HCV and develop HBV-related diseases for the TLR3 gene. Large-scale studies with racially diverse populations are required to validate these findings.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
The low diagram of included/excluded studies.
FIGURE 2
FIGURE 2
Meta-analysis for association between rs3775291 and the risk of HCV infection by the fixed-effects model. HCV = hepatitis C virus.
FIGURE 3
FIGURE 3
Meta-analysis for association between TLR3 polymorphisms and the risk of HBV-related diseases by the fixed-effects model.
See this image and copyright information in PMC

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