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Observational Study
. 2016 May;95(21):e3783.
doi: 10.1097/MD.0000000000003783.

Association Between Histone Methyltransferase hSETD1A and Prognosis in Patients With Triple-Negative Breast Cancer After Surgery: A Retrospective Study in the Chinese Female Population

YanYan Zhu  1 , Kai Bai, JianPing Yu, MeiYan Guo
Affiliations
Observational Study

Association Between Histone Methyltransferase hSETD1A and Prognosis in Patients With Triple-Negative Breast Cancer After Surgery: A Retrospective Study in the Chinese Female Population

YanYan Zhu et al. Medicine (Baltimore). 2016 May.

Abstract

Breast cancer, the most common cancer in women, is a serious public health issue. Triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2, accounts for ∼15% of breast cancer cases. Treatment of TNBC patients has proven difficult because of the lack of expression of hormone receptors. We conducted a retrospective study to investigate the prognostic impact of histone methyltransferase, hSETD1A, on overall survival in TNBC cases after surgery. In total, 159 TNBC cases were enrolled and clinicopathological characteristics were obtained from medical records. hSETD1A status of each subject was determined using immunohistochemistry. The chi-squared test was used to compare 5-year overall survival rates of all subjects according to clinical characteristics, and both univariate and multivariate analyses were conducted to calculate the hazard ratios and 95% confidence intervals. Advanced tumor-node-metastasis stage stage, larger tumor size, vascular invasion, metastasis in the initial diagnosis, and hSETD1A expression were correlated with worse outcome. Among all factors identified, metastasis in the initial diagnosis had the greatest impact on survival. The results indicated that hSETD1A positivity was correlated with shorter survival among TNBC cases, suggesting it may serve as a prognostic biomarker for patients with TNBC.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Immunohistochemical analysis of hSETD1A expression: (A) hSETD1A-positive and (B) hSETD1A-negative.
FIGURE 2
FIGURE 2
Kaplan–Meier analysis of overall survival in 159 TNBC cases in relation to the hSETD1A status. TNBC = triple-negative breast cancer.
FIGURE 3
FIGURE 3
The quantitated hSETD1A expression between 30 paired TNBC and noncancerous samples. TNBC = triple-negative breast cancer.
See this image and copyright information in PMC

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