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Comment
. 2016 Aug;64(2):671-4.
doi: 10.1002/hep.28653. Epub 2016 Jun 24.

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Mirjam B Zeisel  1   2 , Thomas F Baumert  1   2   3
Affiliations
Comment

Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma

Mirjam B Zeisel et al. Hepatology. 2016 Aug.
No abstract available

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Figures

Figure 1
Figure 1. Overview of translated and non-translated genes.
Using a new computational method (RibORF) to systematically analyze ribosome profiling data, Ji and colleagues assessed to which extent ncRNAs are translated into small proteins or peptides and report that approximately 40% of lncRNAs, pseudogene RNA and UTRs of mRNAs are translated into peptides longer than 10 amino acids. Abbreviations: aa: amino acid; lncRNA: long noncoding RNA; mRNA: messenger RNA; ncRNA: non-coding RNA.
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References

    1. Ji Z, Song R, Regev A, Struhl K. Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins. eLife. 2015;4:e08890. - PMC - PubMed
    1. Huang JL, Zheng L, Hu YW, Wang Q. Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma. Carcinogenesis. 2014;35:507–514. - PubMed
    1. George J, Patel T. Noncoding RNA as therapeutic targets for hepatocellular carcinoma. Semin Liver Dis. 2015;35:63–74. - PMC - PubMed
    1. Zhou CC, Yang F, Yuan SX, Ma JZ, Liu F, Yuan JH, Bi FR, et al. Systemic genome screening identified the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. Hepatology. 2016;63:850–863. - PubMed
    1. Charley PA, Wilusz J. Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs. Virus Res. 2016;212:70–77. - PMC - PubMed

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