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. 1977 Dec 30;127(1):1-7.
doi: 10.1007/BF00465559.

Vacuolated lymphocytes in type II glycogenosis--a diagnostic approach?

D B von Bassewitz, H J Bremer, M Bourgeois, H Gröbe, J Stoermer

Vacuolated lymphocytes in type II glycogenosis--a diagnostic approach?

D B von Bassewitz et al. Eur J Pediatr. .

Abstract

Using electron microscopy, glycogen-filled lysosomes were found in peripheral lymphocytes in 5 cases of the infantile form of glycogenosis type II. In two infants whose blood smears were available, the ultrastructural demonstration of this pathognomonic storage corresponded to well-delineated vacuoles detected by routine light microscopy. Detection of such vacuoles in peripheral lymphocytes by light microscopy and demonstration of glycogen-filled lysosomes by electron microscopy could be a simple and harmless tool for diagnosing the classical form of type II glycogenosis.

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