Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun;5(2):201-5.
doi: 10.1007/s40121-016-0111-4. Epub 2016 May 26.

Acute Angioedema Triggered by Daptomycin

Valentin Gisler  1 , Sabine Müller  2 , Lionel Müller  3 , Lukas Jörg-Walther  4 , Parham Sendi  5
Affiliations

Acute Angioedema Triggered by Daptomycin

Valentin Gisler et al. Infect Dis Ther. 2016 Jun.

Abstract

Introduction: Daptomycin is a cyclic lipopeptide antibiotic, frequently administered for Staphylococcus aureus bloodstream infections. Numerous studies have shown that daptomycin is relatively safe and well tolerated. Serious adverse events possibly related to this antimicrobial compound are rare. We report a case of acute angioedema triggered by daptomycin.

Case report: A 60-year-old woman with S. aureus bacteremia without identified source was treated intravenously with high-dose beta-lactams at our institution. Because S. aureus bacteremia persisted on day 6, and in parallel, acute kidney injury developed, antimicrobial treatment was switched to a combination therapy with daptomycin and ceftriaxone. Shortly after completion of the first daptomycin administration, the patient developed lip and tongue swelling and dyspnea. Acute angioedema was clinically evident. Antibiotic therapy was switched to vancomycin, and the further clinical course was favorable. An intradermal test showed a significant wheal diameter for daptomycin, but negative results for ceftriaxone.

Conclusion: The association with daptomycin in this case is either probable or certain. Clinicians should be aware that daptomycin can cause immediate-type hypersensitivity reactions, including acute angioedema, even upon first administration.

Keywords: Anaphylaxis; Angioedema; Daptomycin.

PubMed Disclaimer

References

    1. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPa.... Accessed 10 May 2016.
    1. http://www.swissmedicinfo.ch. Accessed 10 May 2016.
    1. Seaton RA, Menichetti F, Dalekos G, Beiras-Fernandez A, Nacinovich F, Pathan R, Hamed K. Evaluation of effectiveness and safety of high-dose daptomycin: results from patients included in the European Cubicin® outcomes registry and experience. Adv Ther. 2015;32(12):1192–1205. doi: 10.1007/s12325-015-0267-4. - DOI - PMC - PubMed
    1. Mehta S, Singh C, Plata KB, Chanda PK, Paul A, Riosa S, Rosato RR, Rosato AE. beta-Lactams increase the antibacterial activity of daptomycin against clinical methicillin-resistant Staphylococcus aureus strains and prevent selection of daptomycin-resistant derivatives. Antimicrob Agents Chemother. 2012;56(12):6192–6200. doi: 10.1128/AAC.01525-12. - DOI - PMC - PubMed
    1. Praga M, González E. Acute interstitial nephritis. Kidney Int. 2010;77(11):956–961. doi: 10.1038/ki.2010.89. - DOI - PubMed