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Review
. 2016 May 26:17:230.
doi: 10.1186/s12891-016-1085-9.

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review

Julien Freitag  1 , Dan Bates  2 , Richard Boyd  3 , Kiran Shah  4 , Adele Barnard  5 , Leesa Huguenin  2 , Abi Tenen  3
Affiliations
Review

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review

Julien Freitag et al. BMC Musculoskelet Disord. .

Abstract

Osteoarthritis is a leading cause of pain and disability across the world. With an aging population its prevalence is likely to further increase. Current accepted medical treatment strategies are aimed at symptom control rather than disease modification. Surgical options including joint replacement are not without possible significant complications. A growing interest in the area of regenerative medicine, led by an improved understanding of the role of mesenchymal stem cells in tissue homeostasis and repair, has seen recent focused efforts to explore the potential of stem cell therapies in the active management of symptomatic osteoarthritis. Encouragingly, results of pre-clinical and clinical trials have provided initial evidence of efficacy and indicated safety in the therapeutic use of mesenchymal stem cell therapies for the treatment of knee osteoarthritis. This paper explores the pathogenesis of osteoarthritis and how mesenchymal stem cells may play a role in future management strategies of this disabling condition.

Keywords: Knee; Mesenchymal Stem Cells; Osteoarthritis.

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References

    1. Bitton R. The economic burden of osteoarthritis. Am J Manag Care. 2009;15(8):230–235. - PubMed
    1. Fransen M, Bridgett L, March L, et al. The epidemiology of osteoarthritis in Asia. Int J Rheum Dis. 2011;14(2):113–121. doi: 10.1111/j.1756-185X.2011.01608.x. - DOI - PubMed
    1. Brooks PM. Impact of osteoarthritis on individuals and society: how much disability? Social consequences and health economic implications. Curr Opin Rheumatol. 2002;14(5):573–577. doi: 10.1097/00002281-200209000-00017. - DOI - PubMed
    1. Peat G, McCarney R, et al. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis. 2001;60(2):91–97. doi: 10.1136/ard.60.2.91. - DOI - PMC - PubMed
    1. Gupta S, Hawker GA, et al. The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of individuals living with this condition. Rheumatology. 2005;44(12):1531–1537. doi: 10.1093/rheumatology/kei049. - DOI - PubMed

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