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Comment
. 2016 May 27;18(6):589-90.
doi: 10.1038/ncb3365.

PGC1α drives a metabolic block on prostate cancer progression

Martina Wallace  1 , Christian M Metallo  1   2
Affiliations
Free article
Comment

PGC1α drives a metabolic block on prostate cancer progression

Martina Wallace et al. Nat Cell Biol. .
Free article

Abstract

Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.

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