Replicating repetitive DNA
- PMID: 27230530
- DOI: 10.1038/ncb3367
Replicating repetitive DNA
Abstract
The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
Comment on
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Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.Nat Cell Biol. 2016 Jun;18(6):684-91. doi: 10.1038/ncb3344. Epub 2016 Apr 25. Nat Cell Biol. 2016. PMID: 27111843 Free PMC article.
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