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Review
. 2016 May 26;15(1):42.
doi: 10.1186/s12943-016-0525-3.

Essential role of miRNAs in orchestrating the biology of the tumor microenvironment

Jamie N Frediani  1 , Muller Fabbri  2   3   4
Affiliations
Review

Essential role of miRNAs in orchestrating the biology of the tumor microenvironment

Jamie N Frediani et al. Mol Cancer. .

Abstract

MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review focuses on the state-of-the-art knowledge of the role of miRNAs in the complexity of the TME and highlights limitations and challenges in the field. A better understanding of the mechanisms of action of these fascinating micro molecules will lead to the development of new therapeutic weapons and most importantly, to an improvement in the clinical outcome of cancer patients.

Keywords: Cancer; Exosomes; Tumor microenvironment; microRNAs.

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Figures

Fig. 1
Fig. 1
Central role of the miR-17-92 cluster in the biology of the TME. The miR-17-92 cluster encoding miR-17, −18a, −19b, −20a, and -92a is upregulated in multiple tumor types and interacts with various components of the TME to finely “tune” the TME through a complex combination of pro- and anti-tumoral effects
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References

    1. Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373–83. doi: 10.1083/jcb.201211138. - DOI - PMC - PubMed
    1. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science. 2007;318(5858):1931–4. doi: 10.1126/science.1149460. - DOI - PubMed
    1. Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D. MicroRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol. 2003;13(10):807–18. doi: 10.1016/S0960-9822(03)00287-2. - DOI - PubMed
    1. Lin SL, Miller JD, Ying SY. Intronic microRNA (miRNA) J Biomed Biotechnol. 2006;2006(4):26818. - PMC - PubMed
    1. Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov. 2013;12(11):847–65. doi: 10.1038/nrd4140. - DOI - PMC - PubMed

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