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. 2016 Jun 23;120(24):5505-12.
doi: 10.1021/acs.jpcb.6b02519. Epub 2016 Jun 10.

Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part I: Emulsions

M Schmiele  1 , S Busch  2 , H Morhenn  3 , T Schindler  1 , T Schmutzler  1 , R Schweins  4 , P Lindner  4 , P Boesecke  5 , M Westermann  6 , F Steiniger  6 , Sérgio S Funari  7 , T Unruh  1
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Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part I: Emulsions

M Schmiele et al. J Phys Chem B. .

Abstract

The structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-stabilized colloidal tetracosane emulsions was investigated by photon correlation spectroscopy and small-angle X-ray and neutron scattering, using emulsions with different neutron scattering contrasts. Special emphasis was placed on the structure of the DMPC stabilizer layer covering the emulsion droplets. A monolayer, structurally similar to a half DMPC bilayer, with a thickness of 16 Å is found. Thereby, the phosphocholine headgroups arrange flat at the oil-water interface. A deep penetration of the tetracosane oil into the stabilizer layer can be ruled out.

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