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Review
. 2016 May 24;5(2):23.
doi: 10.3390/biology5020023.

The Function of Fish Cytokines

Jun Zou  1 , Christopher J Secombes  2
Affiliations
Review

The Function of Fish Cytokines

Jun Zou et al. Biology (Basel). .

Abstract

What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have focused on the induced effects of cytokine recombinant proteins, or have used loss- and gain-of-function experiments in zebrafish. Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines. This knowledge will aid our ability to determine and modulate the pathways leading to protective immunity, to improve fish health in aquaculture.

Keywords: bioactivity; colony stimulating factors; cytokines; interferons; interleukins; loss- and gain-of-function; recombinant proteins; transforming growth factor-β; tumour necrosis factors.

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Figures

Figure 1
Figure 1
Interaction of the IL-1 family cytokines and receptors. The homologues identified in fish are indicated in red.
See this image and copyright information in PMC

References

    1. Secombes C.J., Wang T.H., Bird S. The interleukins of fish. Dev. Comp. Immunol. 2011;35:1336–1345. doi: 10.1016/j.dci.2011.05.001. - DOI - PubMed
    1. Wang T., Secombes C.J. The cytokine networks of adaptive immunity in fish. Fish Shellfish Immunol. 2013;35:1703–1718. doi: 10.1016/j.fsi.2013.08.030. - DOI - PubMed
    1. Secombes C.J., Zou J., Bird S. Cytokines of cartilaginous fish. In: Smith S.L., Sim R.B., Flajnik M.F., editors. Immunobiology of the Shark. CRC Press; Boca Raton, FL, USA: 2015. pp. 123–142.
    1. Secombes C.J., Wang T., Bird S. Vertebrate cytokines and their evolution. In: Malagoli D., editor. The Evolution of the Immune System: Conservation and Diversification. Academic Press Inc.; Cambridge, MA, USA: 2016. pp. 87–151. Chapter 5.
    1. Bird S., Tafalla C. Teleost chemokines and their receptors. Biology. 2015;4:756–784. doi: 10.3390/biology4040756. - DOI - PMC - PubMed

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