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Review
. 2016 Aug;24(4):470-5.
doi: 10.1080/09273948.2016.1175642. Epub 2016 May 27.

Review for Disease of the Year: Epidemiology of HLA-B27 Associated Ocular Disorders

Laura J Kopplin  1 , George Mount  1 , Eric B Suhler  1   2
Affiliations
Review

Review for Disease of the Year: Epidemiology of HLA-B27 Associated Ocular Disorders

Laura J Kopplin et al. Ocul Immunol Inflamm. 2016 Aug.

Abstract

Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8-10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2-4%) Americans. A group of systemic inflammatory diseases, the spondyloarthropathies, similarly demonstrates a strong association with HLA-B27. The strength of association varies, depending on the specific spondyloarthropathy, with the strongest association found in patients with ankylosing spondylitis. The majority of patients with HLA-B27 associated uveitis will have an underlying spondyloarthropathy. Suspicion for HLA-B27 associated uveitis should prompt a careful clinical history to assess for features of a spondyloarthropathy as the characteristics of any associated uveitis may vary.

Keywords: Acute anterior uveitis; HLA-B27; epidemiology; iritis; spondyloarthropathy.

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Conflict of interest statement

Declaration of Interest:

The authors have no relevant financial conflicts.

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