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. 2016 Jun 15:295-296:9-11.
doi: 10.1016/j.jneuroim.2016.04.001. Epub 2016 Apr 9.

Antibodies to myelin basic protein are associated with cognitive decline after stroke

Kyra J Becker  1 , Patricia Tanzi  2 , Dannielle Zierath  2 , Marion S Buckwalter  3
Affiliations

Antibodies to myelin basic protein are associated with cognitive decline after stroke

Kyra J Becker et al. J Neuroimmunol. .

Abstract

B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).

Keywords: Autoimmune; Cognitive decline; MBP antibodies; Stroke.

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References

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