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. 2016 Jul:23:226-239.
doi: 10.1016/j.fsigen.2016.05.007. Epub 2016 May 12.

Developmental validation of STRmix™, expert software for the interpretation of forensic DNA profiles

Jo-Anne Bright  1 , Duncan Taylor  2 , Catherine McGovern  3 , Stuart Cooper  3 , Laura Russell  3 , Damien Abarno  4 , John Buckleton  3
Affiliations

Developmental validation of STRmix™, expert software for the interpretation of forensic DNA profiles

Jo-Anne Bright et al. Forensic Sci Int Genet. 2016 Jul.

Abstract

In 2015 the Scientific Working Group on DNA Analysis Methods published the SWGDAM Guidelines for the Validation of Probabilistic Genotyping Systems [1]. STRmix™ is probabilistic genotyping software that employs a continuous model of DNA profile interpretation. This paper describes the developmental validation activities of STRmix™ following the SWGDAM guidelines. It addresses the underlying scientific principles, and the performance of the models with respect to sensitivity, specificity and precision and results of interpretation of casework type samples. This work demonstrates that STRmix™ is suitable for its intended use for the interpretation of single source and mixed DNA profiles.

Keywords: Continuous method; DNA mixtures; Probabilistic genotyping; STRmix; Validation.

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