Prenatal Screening for Thrombophilias: Indications and Controversies, an Update

Abstract

Pregnancy is associated with increased clotting potential and decreased fibrinolysis. Women with thrombophilias have an increased risk of venous thromboembolism during pregnancy. At least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia. Acquired thrombophilias have also been linked with adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal demise, early onset severe preeclampsia, placental abruption, and fetal growth restriction. This article addresses indications for thrombophilia testing, the appropriate laboratory tests, and timing of testing to ensure reliability of results.

Keywords: Acquired thrombophilias; Adverse pregnancy outcomes; Inherited thrombophilias; Pregnancy; Thrombophilia; Venous thromboembolism.