Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov;50(6):482-485.
doi: 10.4132/jptm.2016.02.27. Epub 2016 May 29.

Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1

Youngjin Kang  1 , Jung-Woo Choi  1 , Younghye Kim  1 , Hwa Eun Oh  1 , Ju-Han Lee  1 , Young-Sik Kim  1
Affiliations

Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1

Youngjin Kang et al. J Pathol Transl Med. 2016 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
The rectum shows a combined occurrence of goblet cell carcinoid (GCC, empty arrows) and neuroendocrine tumors (filled arrows) as well as neurofibromatosis (A). GCC is mostly composed of small nests of signet-ring-like goblet cells (B), and the cytoplasmic mucin is readily identified with alcian blue pH 2.5 (C). (D) Synaptophysin immunostain clearly shows a few scattered neuroendocrine cells in GCC.
Fig. 2.
Fig. 2.
Neuroendocrine tumors (NETs) consist of small uniform cells which exclusively form trabecular structures (A) and diffusely stained with synaptophysin (B). In the vicinity of both goblet cell carcinoid and NETs, proliferation of slender spindle cells morphologically compatible with neurofibromatosis (C) is evident with S-100 protein immunostain (D).
Fig. 3.
Fig. 3.
The submucosal tumor in the jejunum is composed of bland-looking spindle cells (A) which highly expressed c-Kit by immunohistochemistry (B).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Agaimy A, Vassos N, Croner RS. Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen’s disease): clinicopathological spectrum with pathogenetic considerations. Int J Clin Exp Pathol. 2012;5:852–62. - PMC - PubMed
    1. Rindi G, Klimstra DS, Arnold R, et al. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. 4th ed. Lyon: IARC Press; 2010. Nomenclature and classification of neuroendocrine neoplasms of the digestive system; pp. 13–4.
    1. Gui X, Qin L, Gao ZH, Falck V, Harpaz N. Goblet cell carcinoids at extraappendiceal locations of gastrointestinal tract: an underrecognized diagnostic pitfall. J Surg Oncol. 2011;103:790–5. - PubMed
    1. Hofler H, Kloppel G, Heitz PU. Combined production of mucus, amines and peptides by goblet-cell carcinoids of the appendix and ileum. Pathol Res Pract. 1984;178:555–61. - PubMed
    1. Stancu M, Wu TT, Wallace C, Houlihan PS, Hamilton SR, Rashid A. Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. Mod Pathol. 2003;16:1189–98. - PubMed

LinkOut - more resources