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Comment
. 2016 Jul;22(7):530-533.
doi: 10.1016/j.molmed.2016.05.001. Epub 2016 May 26.

Sarcomeres and Cardiac Growth: Tension in the Relationship

Saptarsi M Haldar  1 , Deepak Srivastava  2
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Comment

Sarcomeres and Cardiac Growth: Tension in the Relationship

Saptarsi M Haldar et al. Trends Mol Med. 2016 Jul.

Abstract

Genetic mutations in the cardiomyocyte contractile apparatus cause aberrant cardiac growth categorized morphologically as hypertrophic or dilated. A recent study leverages an array of mutant mouse models to extrapolate a new integrated parameter: the myofilament 'tension index', which predicts patterns of cardiac growth resulting from individual sarcomeric mutations. These findings may inform genotype-specific therapies.

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  • A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.
    Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD. Davis J, et al. Cell. 2016 May 19;165(5):1147-1159. doi: 10.1016/j.cell.2016.04.002. Epub 2016 Apr 21. Cell. 2016. PMID: 27114035 Free PMC article.

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