Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Sep 15;3(3):177-9.
doi: 10.3748/wjg.v3.i3.177.

Analysis of fibronectin, fibronectin receptor and interleukin-1 in patients with cirrhosis treated by the Yanggan Jieyu decoction

H Wu  1 , J S Gao  1 , J Z Fan  1 , J Huang  1 , J W Deng  1
Affiliations

Analysis of fibronectin, fibronectin receptor and interleukin-1 in patients with cirrhosis treated by the Yanggan Jieyu decoction

H Wu et al. World J Gastroenterol. .

Abstract

Aim: To investigate the effects of the Yanggan Jieyu (YGJY, nourishing the liver and alleviating mental depression) decoction on the plasma concentrations of fibronectin (FN), fibronectin receptor (FNR), tumor necrosis factor alpha (TNF-α), and the activity of interleukin-1 (IL-1) in patients with cirrhosis.

Methods: Thirty-four cases of decompensated cirrhosis were divided into the YGJY decoction treatment group and the control group (patients received standard treatment). FN, FNR and TNF-α were measured by ELISA and expressed as mg/L (FN, FNR) and ng/L (TNF-α). IL-1 was measured by mice thymocyte proliferation using a β scintillation counter and was expressed as cpm.

Results: In the YGJY decoction treatment group, FN and TNF-α levels increased significantly (P < 0.01 and P < 0.05, respectively), and FNR and IL-1 levels decreased significantly (P < 0.05 and P < 0.05, respectively). In the control group, FN, FNR, TNF-α, and IL-1 levels did not significantly change.

Conclusion: YGJY decoction could prevent hepatic fibrosis by adjusting the plasma levels of FN, FNR, TNF-α and IL-1, which could mediate cirrhosis formation. This data is of clinical significance.

Keywords: Fibronectin; Fibronectin receptors; Interleukin-1; Liver cirrhosis; Traditional Chinese Medicine; Tumor necrosis factor; Yanggan Jieyu decoction.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Serum FNR level in relation with plasma FN in 34 patients with chronic liver diseases (liver cirrhosis).
Figure 2
Figure 2
Serum levels of fibronectin in the hepatic fibrosis patients treated with the YGJY (Yanggan Jieyu) decoction.
Figure 3
Figure 3
Serum levels of the fibronectin receptor in the hepatic fibrosis patients treated with YGJY (Yanggan Jieyu) decoction.
Figure 4
Figure 4
Tumor necrosis factor released in hepatic fibrosis patients treated with the YGJY (Yanggan Jieyu) decoction.
Figure 5
Figure 5
Interleukin-1 release in hepatic fibrosis patients treated with the YGJY (Yanggan Jieyu) decoction.
See this image and copyright information in PMC

References

    1. Yamauchi M, Nakajima H, Ohata M, Hirakawa J, Mizuhara Y, Nakahara M, Kimura K, Fujisawa K, Kameda H. Detection of fibronectin receptor in sera: its clinical significance as a parameter of hepatic fibrosis. Hepatology. 1991;14:244–250. - PubMed
    1. Gabrielli GB, Casaril M, Bonazzi L, Baracchino F, Bellisola G, Corrocher R. Plasma fibronectin in liver cirrhosis and its diagnostic value. Clinica Chimica Acta. 1986;160:289–296. - PubMed
    1. Matsuoka M, Pham NT, Tsukamoto H. Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver. 1989;9:71–78. - PubMed
    1. Wu H, Wang ZM, Fan JT, Deng JW, Fen TJ. Effect of six kinds of decoctions on experimental autoimmune liver diseases. Bulletin of Hunan Medical University. 1991;16:263–267.
    1. Chen JZ, Li ZM. Internal medicine. Ed 3. Beijing: The People-s Medical Publishing House; 1989. pp. 389–396.

LinkOut - more resources