Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016:2016:8525679.
doi: 10.1155/2016/8525679. Epub 2016 Apr 30.

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Mayank Sharma  1 , Rajesh Sharma  1 , Dinesh Kumar Jain  2
Affiliations
Review

Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Mayank Sharma et al. Scientifica (Cairo). 2016.

Abstract

Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these systems in the treatment of hypertension continues to broaden. The present review focuses on various nanocarriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Reasons for poor oral bioavailability of poorly water soluble drugs.
Figure 2
Figure 2
Comparison of in vitro drug release profiles of Telmisartan (TLM) loaded nanosuspension, marketed formulation, and conventional tablets.
Figure 3
Figure 3
Comparison of in vitro drug release profile of SNEDDS containing valsartan powder with valsartan tablet.
See this image and copyright information in PMC

References

    1. Agrawal U., Sharma R., Gupta M., Vyas S. P. Is nanotechnology a boon for oral drug delivery? Drug Discovery Today. 2014;19(10):1530–1546. doi: 10.1016/j.drudis.2014.04.011. - DOI - PubMed
    1. Wang X.-Q., Zhang Q. PH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics. 2012;82(2):219–229. doi: 10.1016/j.ejpb.2012.07.014. - DOI - PubMed
    1. Li H., Zhao X., Ma Y., Zhai G., Li L., Lou H. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. Journal of Controlled Release. 2009;133(3):238–244. doi: 10.1016/j.jconrel.2008.10.002. - DOI - PubMed
    1. Khadka P., Ro J., Kim H., et al. Pharmaceutical particle technologies: an approach to improve drug solubility, dissolution and bioavailability. Asian Journal of Pharmaceutical Sciences. 2014;9(6):304–316. doi: 10.1016/j.ajps.2014.05.005. - DOI
    1. Hetal T., Bindesh P., Sneha T. A review on techniques for oral bioavailability enhancement of drugs. International Journal of Pharmaceutical Sciences Review and Research. 2010;4(3):203–223.

LinkOut - more resources