Erythropoietin in ophthalmology: A literature review
- PMID: 27239595
- PMCID: PMC4881220
- DOI: 10.1016/j.joco.2016.01.008
Erythropoietin in ophthalmology: A literature review
Abstract
Purpose: To review the current literature on ocular application of erythropoietin (EPO).
Methods: A comprehensive search was performed on Pubmed and Scopus databases. All selected articles were reviewed thoroughly by the authors to review current applications of the EPO in ocular diseases.
Results: Various aspects of administration of EPO for different ischemic, traumatic, vascular, and degenerative disorders have been explained. The articles are generally preclinical with few small studies reporting clinical outcomes.
Conclusion: EPO has been used for the treatment of different ophthalmic conditions with promising results. Further studies are needed to elaborate the role of EPO in management of ocular diseases.
Keywords: Apoptosis; Erythropoietin; Neuroprotection.
Similar articles
-
Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis.J Perinat Med. 2019 May 27;47(4):478-489. doi: 10.1515/jpm-2018-0360. J Perinat Med. 2019. PMID: 30789826
-
Revisiting the role of erythropoietin for treatment of ocular disorders.Eye (Lond). 2016 Oct;30(10):1293-1309. doi: 10.1038/eye.2016.94. Epub 2016 Jun 10. Eye (Lond). 2016. PMID: 27285322 Free PMC article. Review.
-
Contemporary uses of erythropoietin in pregnancy: a literature review.Obstet Gynecol Surv. 2013 Aug;68(8):594-602. doi: 10.1097/OGX.0b013e3182a2d51c. Obstet Gynecol Surv. 2013. PMID: 23921673 Review.
-
Therapeutic strategy of erythropoietin in neurological disorders.CNS Neurol Disord Drug Targets. 2008 Jun;7(3):227-34. doi: 10.2174/187152708784936617. CNS Neurol Disord Drug Targets. 2008. PMID: 18673207 Review.
-
Erythropoietin as a novel neuroprotectant.Restor Neurol Neurosci. 2004;22(2):105-19. Restor Neurol Neurosci. 2004. PMID: 15272145 Review.
Cited by
-
Visual Outcomes of Adding Erythropoietin to Methylprednisolone for Treatment of Retrobulbar Optic Neuritis.J Ophthalmic Vis Res. 2019 Jul 18;14(3):299-305. doi: 10.18502/jovr.v14i3.4786. eCollection 2019 Jul-Sep. J Ophthalmic Vis Res. 2019. PMID: 31660109 Free PMC article. Review.
-
Serum erythropoietin concentration and its correlation with stage of diabetic retinopathy.BMC Ophthalmol. 2019 Nov 14;19(1):227. doi: 10.1186/s12886-019-1240-9. BMC Ophthalmol. 2019. PMID: 31727007 Free PMC article.
-
Combination of intravitreal bevacizumab and erythropoietin versus intravitreal bevacizumab alone for refractory diabetic macular edema: a randomized double-blind clinical trial.Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2375-2380. doi: 10.1007/s00417-019-04383-2. Epub 2019 Aug 10. Graefes Arch Clin Exp Ophthalmol. 2019. PMID: 31401683 Clinical Trial.
-
Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy.J Ophthalmol. 2018 Dec 16;2018:2750632. doi: 10.1155/2018/2750632. eCollection 2018. J Ophthalmol. 2018. PMID: 30647957 Free PMC article.
-
Delayed reversal of methanol-induced blindness in an adult by a combination of erythropoietin and a high dose of methylprednisolone: a case report.J Med Case Rep. 2023 Apr 20;17(1):181. doi: 10.1186/s13256-023-03899-w. J Med Case Rep. 2023. PMID: 37076901 Free PMC article.
References
-
- Genc S., Koroglu T.F., Genc K. Erythropoietin and the nervous system. Brain Res. 2004;1000:19–31. - PubMed
-
- Fried W., Kilbridge T., Krantz S., McDonald T.P., Lange R.D. Studies on extrarenal erythropoietin. J Lab Clin Med. 1969;73:244–248. - PubMed
-
- Bogoyevitch Marie A. An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection. Cardiovasc Research. 2004;63:208–216. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials