Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Mar 9;15(4):182-4.
doi: 10.1016/j.tjem.2014.09.002. eCollection 2015 Dec.

Methemoglobinemia caused by dapsone overdose: Which treatment is best?

Ibrahim Toker  1 , Murat Yesilaras  1 , Feriyde Caliskan Tur  1 , Rana Toktas  1
Affiliations
Case Reports

Methemoglobinemia caused by dapsone overdose: Which treatment is best?

Ibrahim Toker et al. Turk J Emerg Med. .

Abstract

Increase of methemoglobin level is named as methemoglobinemia characterized by functional anemia and tissue hypoxia. Methemoglobinemia can be congenital, but acquired form are more often caused by various drugs and toxins. Methylene blue is the most effective antidote for acquired methemoglobinemia. When methylene blue is not available, alternative treatments such as ascorbic acid and hyperbaric oxygen can be useful. In this paper we presented a case of methomoglobinemia due to dapsone overdose.

Keywords: Dapsone overdose; Emergency medicine; Methemoglobinemia.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Chronologic observation of patient's methemoglobin levels and its relation with treatments.
See this image and copyright information in PMC

References

    1. El-Husseini A., Azarov N. Is threshold for treatment of methemoglobinemia the same for all? A case report and literature review. Am J Emerg Med. 2010;28:748.e5–748.e10. - PubMed
    1. Wright R.O., Lewander W.J., Woolf A.D. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med. 1999;34:646–656. - PubMed
    1. Falkenhahn M., Kannan S., O'Kane M. Unexplained acute severe methaemoglobinaemia in a young adult. Br J Anaesth. 2001;86:278–280. - PubMed
    1. Ash-Bernal R., Wise R., Wright S.M. Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore) 2004;83:265–273. - PubMed
    1. Burke P., Jahangir K., Kolber M.R. Dapson İnduced methemoglobinemia. Can Fam Physician. 2013;59:958–961. - PMC - PubMed

Publication types

LinkOut - more resources