Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 1;106(3):723-30.
doi: 10.1016/j.fertnstert.2016.05.015. Epub 2016 May 27.

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

Alexandra J White  1 , Dale P Sandler  2 , Aimee A D'Aloisio  3 , Frank Stanczyk  4 , Kristina W Whitworth  5 , Donna D Baird  2 , Hazel B Nichols  6
Affiliations

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

Alexandra J White et al. Fertil Steril. .

Abstract

Objective: To evaluate exposure to tobacco, marijuana, and indoor heating/cooking sources in relation to antimüllerian hormone (AMH) levels.

Design: Cross-sectional analysis in a sample of premenopausal women (n = 913) enrolled in the Sister Study cohort (n = 50,884).

Setting: Not applicable.

Patient(s): Women, ages 35-54 years at time of enrollment, with an archived serum sample and at least one intact ovary and classified as premenopausal.

Intervention(s): Not applicable.

Main outcome measure(s): Serum AMH (ng/mL) levels ascertained by ultrasensitive ELISA assay.

Result(s): Lower AMH levels were associated with sources of indoor heating, including burning wood (-36.0%; 95% confidence interval [CI], -55.7%, -7.8%) or artificial fire logs (-45.8%; 95% CI, -67.2%, -10.4%) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to nonsmokers (-56.2%; 95% CI, -80.3%, -2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (-31.3%; 95% CI, -51.3%, -3.1%), but no associations were observed for marijuana use.

Conclusion(s): We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial fire logs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary.

Keywords: Anti-Müllerian Hormone; Tobacco; breast cancer; environmental tobacco smoke; indoor air pollution.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: None declared.

References

    1. Visser JA, Schipper I, Laven JS, Themmen AP. Anti-Mullerian hormone: an ovarian reserve marker in primary ovarian insufficiency. Nat Rev Endocrinol. 2012;8:331–41. - PubMed
    1. Lukaszuk K, Liss J, Kunicki M, Jakiel G, Wasniewski T, Woclawek-Potocka I, et al. Anti-Mullerian hormone (AMH) is a strong predictor of live birth in women undergoing assisted reproductive technology. Reprod Biol. 2014;14:176–81. - PubMed
    1. Dolleman M, Depmann M, Eijkemans MJ, Heimensem J, Broer SL, van der Stroom EM, et al. Anti-Mullerian hormone is a more accurate predictor of individual time to menopause than mother’s age at menopause. Hum Reprod. 2014;29:584–91. - PubMed
    1. Nichols HB, Baird DD, Stanczyk FZ, Steiner AZ, Troester MA, Whitworth KW, et al. Anti-Müllerian Hormone Concentrations in Premenopausal Women and Breast Cancer Risk. Cancer Prev Res (Phila) 2015;8:528–34. - PMC - PubMed
    1. Dorgan JF, Stanczyk FZ, Egleston BL, Kahle LL, Shaw CM, Spittle CS, et al. Prospective case-control study of serum mullerian inhibiting substance and breast cancer risk. Journal of the National Cancer Institute. 2009;101:1501–9. - PMC - PubMed

Publication types

MeSH terms