Angiogenesis-related biomarkers (sFlt-1/PlGF) in placental mesenchymal dysplasia

Abstract

Determination of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio (sFlt-1/PlGF) in the maternal serum is expected to aid in the monitoring and decision-making process of women at risk for placental dysfunction. We report two cases of placental mesenchymal dysplasia (PMD) with sFlt-1/PlGF correlation. The first case is a dichorionic twin pregnancy with one fetus affected by PMD and Beckwith-Wiedemann syndrome in which a high value of sFlt-1/PlGF was found, coinciding with acute maternal and fetal wellbeing decline at 31 weeks. The second case corresponds to a singleton pregnancy diagnosed of PMD with normal sFlt-1/PlGF and favorable outcome.

Keywords: Angiogenic factors; Beckwith–Wiedemann syndrome; intrauterine growth restriction; placental dysfunction; placental growth factor; soluble fms-like tyrosine kinase-1.