Natural history of canine paroxysmal movement disorders in Labrador retrievers and Jack Russell terriers

Abstract

Delineation of the typical disease progression in canine paroxysmal dyskinesia (PD) may assist in evaluating therapeutic agents during clinical trials. Our objective was to establish the natural disease course in a group of dogs diagnosed with PD that received no medication. Fifty-nine dogs (36 Labradors, 23 JRTs) with clinically confirmed PD and a follow-up of ≥3 years were retrospectively reviewed. Dogs with PD had a young onset, were triggered by startle or sudden movements, and had a male bias (75%) with the majority being entire sample population. Twenty-one dogs (36%) had at least one event comprising cluster episodes. Episode duration and frequency varied dramatically, even within an individual. Median follow-up was 7 years. No concurrent disease was identified in any dog that was investigated. The natural history was self-limiting with 32% entering remission and an improvement in 75%. Episodes reduced in terms of frequency and duration in Labradors and JRTs respectively. Remission was lower in dogs with cluster episodes than those without. These findings suggest that the diagnostic yield of advanced neuroimaging techniques in dogs with video footage and historical data supporting PD, without neurological deficits, is low. The presence of cluster episodes is of predictive value for the prognosis of canine PD. Future research should be cautious in reporting treatment response for PD without first considering the spontaneous remission rate and improvements in untreated dogs documented in this study.

Keywords: Dog; Dyskinesia; Progression; Seizure; Treatment.