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Review
. 2018 Apr;113(3):174-183.
doi: 10.1007/s00063-016-0156-x. Epub 2016 May 30.

[Acute liver failure]

[Article in German]
K Rutter  1 , T Horvatits  2 , A Drolz  2 , K Roedl  2 , S Siedler  2 , S Kluge  2 , V Fuhrmann  2
Affiliations
Review

[Acute liver failure]

[Article in German]
K Rutter et al. Med Klin Intensivmed Notfmed. 2018 Apr.

Abstract
in English, German

Acute liver failure (ALF) is a rare condition with fatal outcome. Characteristic is rapid onset of liver damage without preexisting liver diseases, including hepatic encephalopathy and coagulopathy. Early and correct diagnosis is essential for further management of patients, since diagnosis impacts therapy choice. Survival of patients with ALF has improved dramatically due to advances in critical care medicine and the use of liver transplantation.

Das akute Leberversagen (ALV) ist ein seltenes, aber lebensbedrohliches Zustandsbild. Charakteristisch ist das rasche Auftreten eines schweren Leberschadens mit hepatozellulärer Nekrose und eingeschränkter Leberfunktion. Bei weiterhin hoher Mortalität ist ein frühzeitiges Erkennen und Einleiten einer ursachenspezifischen unterstützenden sowie v. a. intensivmedizinischen symptomatischen Therapie essenziell. Durch Fortschritte im Bereich der intensivmedizinischen Behandlung von Patienten mit akutem Leberversagen sowie der Lebertransplantation konnte das Überleben deutlich verbessert werden.

Keywords: ALF; Acute liver failure; Critical care medicine.

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References

    1. Trey C, Davidson CS. The management of fulminant hepatic failure. Prog Liver Dis. 1970;3:282–298. - PubMed
    1. Lee WM, Squires RH, Jr., Nyberg SL, Doo E, Hoofnagle JH. Acute liver failure: Summary of a workshop. Hepatology. 2008;47(4):1401–1415. doi: 10.1002/hep.22177. - DOI - PMC - PubMed
    1. O’Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439–445. doi: 10.1016/0016-5085(89)90081-4. - DOI - PubMed
    1. Oketani M, Ido A, Nakayama N, et al. Etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in Japan: Summary of the annual nationwide survey between 2004 and 2009. Hepatol Res. 2013;43(2):97–105. doi: 10.1111/j.1872-034X.2012.01105.x. - DOI - PubMed
    1. Ostapowicz G. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–954. doi: 10.7326/0003-4819-137-12-200212170-00007. - DOI - PubMed

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