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. 2016 May 31;16(1):123.
doi: 10.1186/s12884-016-0919-7.

Reproductive trends in females with inflammatory joint disease

Marianne Wallenius  1   2 , Kjell Å Salvesen  3   4 , Anne K Daltveit  5   6 , Johan F Skomsvoll  7
Affiliations

Reproductive trends in females with inflammatory joint disease

Marianne Wallenius et al. BMC Pregnancy Childbirth. .

Abstract

Background: The study assessed birth trends per decade in offspring of females with inflammatory joint diseases (IJD) compared with women without IJD.

Methods: This retrospective cohort study is based on data from the Medical Birth Registry of Norway from 1967 to 2009. We investigated singleton births in females with IJD (n = 7502) and compared with births from the general population (n = 2 437 110). Four periods were examined: 1967-79, 1980-89, 1990-99 and 2000-09. In the logistic regression analysis adjustments were made for maternal age at delivery and birth order. Odds ratios were obtained for the associations between IJD and birth outcome for each period.

Results: Females with IJD had in average 65 deliveries / year (0.08 % of all births) in the 1970ies and 274 deliveries / year (0.5 % of all births) from 2000 to 2009. Adjusted Odds ratios (aOR) for newborns small for gestational age were 1.5 (95 % CI 1.2, 1.9) in the earliest and 1.1 (95 % CI 0.9, 1.2) in the last period. Correspondingly, for birth weight < 2500 grams aOR decreased from 1.4 (95 % CI 1.0, 1.9) to 1.1 (95 % CI 0.9, 1.4). For preterm birth aOR was 1.1 (95 % CI 0.8, 1.5) in the first and 1.3 (95 % CI (1.1, 1.5) in the last period.

Conclusion: An increasing number of births among females with IJD were observed in the study period. Birth weights of newborns of IJD women approached to birth weights in the general population, but preterm birth remained a problem.

Keywords: Arthritis; Birth registry; Birth weight; Secular trends.

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References

    1. Bowden AP, Barrett JH, Fallow W, Silman AJ. Women with inflammatory polyarthritis have babies of lower birth weight. J Rheumatol. 2001;28:355–9. - PubMed
    1. de Man YA, Hazes JM, van der Helm H, Willemsen SP, de Groot CJ, Steegers EA, et al. Association of higher rheumatoid arthritis disease activity during pregnancy with lower birth weight: Results of a national prospective study. Arthritis Rheum. 2009;60:3196–206. doi: 10.1002/art.24914. - DOI - PubMed
    1. Norgaard M, Larsson H, Pedersen L, Granath F, Askling J, Kieler H, et al. Rheumatoid arthritis and birth outcomes: a Danish and Swedish nationwide prevalence study. J Intern Med. 2010;268:329–37. doi: 10.1111/j.1365-2796.2010.02239.x. - DOI - PubMed
    1. Wallenius M, Skomsvoll JF, Irgens LM, Salvesen KA, Nordvag BY, Koldingsnes W, et al. Pregnancy and delivery in women with chronic inflammatory arthritides with a specific focus on first birth. Arthritis Rheum. 2011;63:1534–42. doi: 10.1002/art.30210. - DOI - PubMed
    1. Skomsvoll JF, Ostensen M, Irgens LM, Baste V. Perinatal outcome in pregnancies of women with connective tissue disease and inflammatory rheumatic disease in Norway. Scand J Rheumatol. 1999;28:352–6. doi: 10.1080/03009749950155337. - DOI - PubMed

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