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Review
. 2016 Sep:55:91-100.
doi: 10.1016/j.humpath.2016.05.008. Epub 2016 May 28.

Ewing sarcoma: a chronicle of molecular pathogenesis

Sang Kyum Kim  1 , Yong-Koo Park  2
Affiliations
Review

Ewing sarcoma: a chronicle of molecular pathogenesis

Sang Kyum Kim et al. Hum Pathol. 2016 Sep.

Abstract

Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific genetic alterations. The genetic alterations are translocations between genes of the TET/FET family (TLS/FUS, EWSR1, and TAF15) and genes of the E26 transformation-specific (ETS) family. In this review, we intend to summarize a chronicle of molecular findings of Ewing sarcoma including recent advances and explain resultant molecular pathogenesis.

Keywords: Chromosomal translocation; Ewing sarcoma; Molecular pathogenesis.

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