Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Jun 1;594(11):2775-6.
doi: 10.1113/JP272183.

Strict glucose control and artificial regulation of the NO-ADMA-DDAH system in order to prevent endothelial dysfunction

Affiliations
Comment

Strict glucose control and artificial regulation of the NO-ADMA-DDAH system in order to prevent endothelial dysfunction

Saskia J H Brinkmann et al. J Physiol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Schematic overview of the interactions between arginine, asymmetric dimethylarginine (ADMA), dimethylarginine dimethylaminohydrolase (DDAH), and nitric oxide synthase (NOS)
PRMTs, protein arginine methyltransferases. Adapted from (Brinkmann et al. 2015).

Comment on

References

    1. EL Assar M, Angulo J, Santos‐Ruiz M, Ruiz de Adana JC, Pindado ML, Sánchez‐Ferrer A, Hernández A & Rodríguez‐Mañas L (2016). Asymmetric dimethylarginine (ADMA) elevation and arginase up‐regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans. J Physiol 594, 3045–3060. - PMC - PubMed
    1. Brinkmann SJ, de Boer MC, Buijs N & van Leeuwen PA (2014). Asymmetric dimethylarginine and critical illness. Curr Opin Clin Nutr Metab Care 17, 90–97. - PubMed
    1. Brinkmann SJ, Worner EA, Buijs N, Richir M, Cynober L, van Leeuwen PA et al (2015). The arginine/ADMA ratio is related to the prevention of atherosclerotic plaques in hypercholesterolemic rabbits when giving a combined therapy with atorvastatine and arginine. Int J Mol Sci 16, 12230–12242. - PMC - PubMed
    1. El AM, Ruiz de Adana JC, Angulo J, Pindado Martinez ML, Hernandez MA & Rodriguez‐Manas L (2013). Preserved endothelial function in human obesity in the absence of insulin resistance. J Transl Med 11, 263. - PMC - PubMed
    1. Kobayashi T, Taguchi K, Yasuhiro T, Matsumoto T & Kamata K (2004). Impairment of PI3‐K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model. Hypertension 44, 956–962. - PubMed

LinkOut - more resources