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Editorial
. 2016 Jun 7;113(23):6330-1.
doi: 10.1073/pnas.1606109113. Epub 2016 May 31.

How to tune an enhancer

Scott Barolo  1
Affiliations
Editorial

How to tune an enhancer

Scott Barolo. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Constraints and trade-offs in enhancer design. DNA sequence features modulate TF function and enhancer activity, directly or indirectly, in many ways. Not depicted are larger scale but equally sequence-driven regulatory mechanisms, such genome compartmentalization, enhancer-promoter pairing, and the combined action of multiple enhancers. A pair of TF sites is shown here for the sake of simplicity, but developmental enhancers in the wild are, as a rule, larger and much more complex.
See this image and copyright information in PMC

Comment in

Comment on

References

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