Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May 11:5:594.
doi: 10.1186/s40064-016-2200-y. eCollection 2016.

Impact of central obesity on prognostic outcome of triple negative breast cancer in Chinese women

Hong-Liang Chen  1 , Ang Ding  1 , Mao-Li Wang  1
Affiliations

Impact of central obesity on prognostic outcome of triple negative breast cancer in Chinese women

Hong-Liang Chen et al. Springerplus. .

Abstract

Purpose: To evaluate the prognostic effect of central obesity on triple negative breast cancer (TNBC).

Methods: 206 TNBC patients treated from June 2006 to June 2015 were enrolled retrospectively. Body mass index (BMI) ≥25 kg/m(2) was the standard of obesity and waist circumference ≥80 cm was the standard of central obesity. Patient and tumor characteristics were compared between obesity categories. Survival differences between obesity categories were assessed with log-rank test in the univariate analysis and prognostic factors were then investigated by Cox regression analysis.

Results: 81 cases were with obesity (39.3 %). 71 cases were with central obesity (34.5 %). Patients with obesity or central obesity tended to be older (P = 0.022 for obesity; P = 0.013 for central obesity) and to have larger tumor size (P = 0.027 for obesity; P = 0.027 for central obesity). By Cox regression analysis, central obesity (DFS: HR 1.759; 95 % CI 1.009-3.065; P = 0.046. OS: HR 2.297; 95 % CI 1.184-4.456; P = 0.014) was identified as an independent prognostic factor. For central obesity with BMI ≥ 25 kg/m(2), the prognostic effect was more apparent (DFS: HR 1.845; 95 % CI 1.059-3.212; P = 0.031. OS: HR 2.377; 95 % CI 1.230-4.593; P = 0.010).

Conclusion: Central obesity, especially with high BMI, was an independent prognostic factor for TNBC.

Keywords: Central obesity; Obesity; Prognosis; Triple negative breast cancer.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Survival curves of TNBC according to obesity categories. a DFS curves according to BMI. b OS curves according to BMI. c DFS curves according to WC. d OS curves according to WC
Fig. 2
Fig. 2
Survival curves of TNBC according to BMI + WC. a DFS curves according to BMI + WC. b OS curves according to BMI + WC
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abrahamson PE, Gammon MD, Lund MJ, Flagg EW, Porter PL, Stevens J, et al. General and abdominal obesity and survival among young women with breast cancer. Cancer Epidemiol Biomark Prev. 2006;15:1871–1877. doi: 10.1158/1055-9965.EPI-06-0356. - DOI - PubMed
    1. Ademuyiwa FO, Groman A, O’Connor T, Ambrosone C, Watroba N, Edge SB. Impact of body mass index on clinical outcomes in triple-negative breast cancer. Cancer. 2011;117:4132–4140. doi: 10.1002/cncr.26019. - DOI - PubMed
    1. Azrad M, Demark-Wahnefried W. The association between adiposity and breast cancer recurrence and survival: a review of the recent literature. Curr Nutr Rep. 2014;3:9–15. doi: 10.1007/s13668-013-0068-9. - DOI - PMC - PubMed
    1. Chan DS, Vieira AR, Aune D, Bandera EV, Greenwood DC, McTiernan A, et al. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 2014;25:1901–1914. doi: 10.1093/annonc/mdu042. - DOI - PMC - PubMed
    1. Chen HL, Ding A. Comparison of invasive micropapillary and triple negative invasive ductal carcinoma of the breast. Breast. 2015;24:723–731. doi: 10.1016/j.breast.2015.09.001. - DOI - PubMed

LinkOut - more resources