Sarcoidosis and T-Helper Cells. Th1, Th17, or Th17.1?

Affiliations

¹ 1 Division of Pulmonary and Critical Care Medicine University of Rochester Medical Center Rochester, New York and.
² 2 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine Ohio State University Wexner Medical Center Columbus, Ohio.

Comment

Steve N Georas et al. Am J Respir Crit Care Med. 2016.

. 2016 Jun 1;193(11):1198-200.

doi: 10.1164/rccm.201512-2419ED.

¹ 1 Division of Pulmonary and Critical Care Medicine University of Rochester Medical Center Rochester, New York and.
² 2 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine Ohio State University Wexner Medical Center Columbus, Ohio.

No abstract available

Comment on

IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.
Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. Ramstein J, et al. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1281-91. doi: 10.1164/rccm.201507-1499OC. Am J Respir Crit Care Med. 2016. PMID: 26649486 Free PMC article.

1. Grunewald J, Spagnolo P, Wahlström J, Eklund A. Immunogenetics of disease-causing inflammation in sarcoidosis. Clin Rev Allergy Immunol. 2015;49:19–35. - PubMed
1. Wahlström J, Katchar K, Wigzell H, Olerup O, Eklund A, Grunewald J. Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am J Respir Crit Care Med. 2001;163:115–121. - PubMed
1. Smith D, Hänsch H, Bancroft G, Ehlers S. T-cell-independent granuloma formation in response to Mycobacterium avium: role of tumour necrosis factor-alpha and interferon-gamma. Immunology. 1997;92:413–421. - PMC - PubMed
1. Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, Kambouchner M, Valeyre D, Chapelon-Abric C, Debré P, et al. The immune paradox of sarcoidosis and regulatory T cells. J Exp Med. 2006;203:359–370. - PMC - PubMed
1. Chen ES, Song Z, Willett MH, Heine S, Yung RC, Liu MC, Groshong SD, Zhang Y, Tuder RM, Moller DR. Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2. Am J Respir Crit Care Med. 2010;181:360–373. - PMC - PubMed