This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2016 Jun 2;374(22):2175-81.

doi: 10.1056/NEJMms1604593.

Assessing the Gold Standard--Lessons from the History of RCTs

Laura E Bothwell¹, Jeremy A Greene¹, Scott H Podolsky¹, David S Jones¹

Affiliations

Affiliation

¹ From the Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (L.E.B.), and the Department of Global Health and Social Medicine, Harvard Medical School (S.H.P., D.S.J.), Boston, and the Department of the History of Science, Harvard University, Cambridge (D.S.J.) - both in Massachusetts; and the Division of General Internal Medicine and the Department of the History of Medicine, Johns Hopkins University School of Medicine, Baltimore (J.A.G.).

PMID: 27248626
DOI: 10.1056/NEJMms1604593

Assessing the Gold Standard--Lessons from the History of RCTs

Laura E Bothwell et al. N Engl J Med. 2016.

. 2016 Jun 2;374(22):2175-81.

doi: 10.1056/NEJMms1604593.

Authors

Laura E Bothwell¹, Jeremy A Greene¹, Scott H Podolsky¹, David S Jones¹

Affiliation

¹ From the Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (L.E.B.), and the Department of Global Health and Social Medicine, Harvard Medical School (S.H.P., D.S.J.), Boston, and the Department of the History of Science, Harvard University, Cambridge (D.S.J.) - both in Massachusetts; and the Division of General Internal Medicine and the Department of the History of Medicine, Johns Hopkins University School of Medicine, Baltimore (J.A.G.).

PMID: 27248626
DOI: 10.1056/NEJMms1604593

No abstract available

PubMed Disclaimer

Similar articles

Rofecoxib, Merck, and the FDA.
Kim PS, Reicin AS. Kim PS, et al. N Engl J Med. 2004 Dec 30;351(27):2875-8; author reply 2875-8. doi: 10.1056/NEJM200412303512719. N Engl J Med. 2004. PMID: 15625342 No abstract available.
Access before approval--a right to take experimental drugs?
Okie S. Okie S. N Engl J Med. 2006 Aug 3;355(5):437-40. doi: 10.1056/NEJMp068132. N Engl J Med. 2006. PMID: 16885545 No abstract available.
The right to a trial: Should dying patients have access to experimental drugs?
Groopman J. Groopman J. New Yorker. 2006 Dec 18:40-7. New Yorker. 2006. PMID: 17176539 No abstract available.
A long and winding road; evolution of antimicrobial drug development - crisis management.
Echols RM. Echols RM. Expert Rev Anti Infect Ther. 2012 Nov;10(11):1311-9. doi: 10.1586/eri.12.131. Expert Rev Anti Infect Ther. 2012. PMID: 23241188 Review.
Cancer drug approval in the United States, Europe, and Japan.
Milsted RA. Milsted RA. Adv Cancer Res. 2007;96:371-91. doi: 10.1016/S0065-230X(06)96012-6. Adv Cancer Res. 2007. PMID: 17161686 Review. No abstract available.

See all similar articles

Cited by

Randomized controlled trials-a critical re-appraisal.
Mielke D, Rohde V. Mielke D, et al. Neurosurg Rev. 2021 Aug;44(4):2085-2089. doi: 10.1007/s10143-020-01401-4. Epub 2020 Oct 6. Neurosurg Rev. 2021. PMID: 33025186 Free PMC article. Review.
Generalisability of randomised trials of the programmed intermittent epidural bolus technique for maintenance of labour analgesia: a prospective single centre cohort study.
Gabriel L, Young J, Hoesli I, Girard T, Dell-Kuster S. Gabriel L, et al. Br J Anaesth. 2019 Aug;123(2):e434-e441. doi: 10.1016/j.bja.2019.02.016. Epub 2019 Mar 28. Br J Anaesth. 2019. PMID: 31331592 Free PMC article.
Hawthorne Effect: More Than Just Telephones.
Nossaman LE, Nossaman BD. Nossaman LE, et al. Ochsner J. 2022 Winter;22(4):286-289. doi: 10.31486/toj.22.5031. Ochsner J. 2022. PMID: 36561101 Free PMC article. No abstract available.
Intervention Tournaments: An Overview of Concept, Design, and Implementation.
Hameiri B, Moore-Berg SL. Hameiri B, et al. Perspect Psychol Sci. 2022 Nov;17(6):1525-1540. doi: 10.1177/17456916211058090. Epub 2022 May 17. Perspect Psychol Sci. 2022. PMID: 35580273 Free PMC article.
Establishing Clinical Utility for Diagnostic Tests Using a Randomized Controlled, Virtual Patient Trial Design.
Peabody J, Tran M, Paculdo D, Valdenor C, Burgon T, Jeter E. Peabody J, et al. Diagnostics (Basel). 2019 Jun 29;9(3):67. doi: 10.3390/diagnostics9030067. Diagnostics (Basel). 2019. PMID: 31261878 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Atypon
- Ovid Technologies, Inc.
Other Literature Sources
- scite Smart Citations