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Review
. 2016 Oct;12(5):524-529.
doi: 10.1007/s12015-016-9665-5.

Stem Cells in Bone Regeneration

Graham G Walmsley  1   2 , Ryan C Ransom  1   2 , Elizabeth R Zielins  1 , Tripp Leavitt  1 , John S Flacco  1 , Michael S Hu  1   2   3 , Andrew S Lee  2 , Michael T Longaker  1   2 , Derrick C Wan  4
Affiliations
Review

Stem Cells in Bone Regeneration

Graham G Walmsley et al. Stem Cell Rev Rep. 2016 Oct.

Abstract

Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing, efforts to characterize bone stem and progenitor cell populations, and the current status of translational and clinical studies in cell-based bone tissue engineering. Though barriers to clinical implementation still exist, the application of stem and progenitor cell populations to bone engineering strategies has the potential to profoundly impact regenerative medicine.

Keywords: Bone; Engineering; Regeneration; Stem cell; Tissue.

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Conflict of interest statement

The authors indicate no potential conflicts of interest

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