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Review
. 2016 Jul;33(7):68.
doi: 10.1007/s12032-016-0782-4. Epub 2016 Jun 1.

The role of IL-37 in cancer

Vivi A Ding  1 , Ziwen Zhu  2 , Huaping Xiao  3 , Mark R Wakefield  2 , Qian Bai  2 , Yujiang Fang  4   5
Affiliations
Review

The role of IL-37 in cancer

Vivi A Ding et al. Med Oncol. 2016 Jul.

Abstract

Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis.

Keywords: Cancer; IL-37; Immunity.

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