ST elevation myocardial infarction
- PMID: 27251920
- PMCID: PMC5922709
- DOI: 10.7861/clinmedicine.16-3-277
ST elevation myocardial infarction
Abstract
ST segment elevation myocardial infarction remains a significant contributor to morbidity and mortality worldwide, despite a declining incidence and better survival rates. It usually results from thrombotic occlusion of a coronary artery at the site of a ruptured or eroded plaque. Diagnosis is based on characteristic symptoms and electrocardiogram changes, and confirmed subsequently by raised cardiac enzymes. Prognosis is dependent on the size of the infarct, presence of collaterals and speed with which the occluded artery is reopened. Mechanical reperfusion by primary percutaneous coronary intervention is superior to fibrinolytic therapy if delivered by an experienced team in a timely fashion. Post-reperfusion care includes monitoring for complications, evaluation of left ventricular function, secondary preventive therapy and cardiac rehabilitation.
Keywords: ST elevation myocardial infarction; fibrinolysis; primary percutaneous coronary intervention.
© 2016 Royal College of Physicians.
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References
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- Myocardial Ischaemia National Audit Project How the NHS cares for ischaemia with heart attack. London: MINAP; 2014. Available online at http://www.ucl.ac.uk/nicor/audits/minap/documents/annual_reports/minap-p.... [Accessed 6 April 2016]
-
- Stone GW. Narula J. The myth of the mild vulnerable plaques. JACC Cardiovasc Imaging. 2013;6:1124–6. - PubMed
-
- Reimer KA. Lowe JE. Rasmussen MM. Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977;56:786–94. - PubMed
-
- Brown AJ. Hoole SP. McCormick LM, et al. Left bundle branch block with acute thrombotic occlusion is associated with increased myocardial jeopardy score and poor clinical outcomes in primary percutaneous coronary intervention activations. Heart. 2013;99:774–8. - PubMed
-
- Roffi M. Patrono C. Collet JP, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) Eur Heart J. 2015;37:267–315. 2016. - PubMed
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